Eva Herker

Eva Herker is at the forefront of investigating the subversion of LDs by various viruses. Her work revealed that triglyceride synthesis via DGAT1 is critical for viral replication and pathogenesis and identified several LD-associated proteins as pro-viral host factors.

ORCID: 0000-0001-9644-2484

eva.herker[at]uni-marburg.de

Herker lab
Herker lab @ UMR

Select Publications

Dengue virus is particularly sensitive to interference with long-chain fatty acid elongation and desaturation
Hehner J, Ludenia L, Bierau L, Schöbel A, Schauflinger M, Grande YF, Schwudke D, Herker E
J Biol Chem 301(3):108222 2025
doi: 10.1016/j.jbc.2025.108222 PMID: 39863099 PMCID: PMC11908578

Glycerophospholipid remodeling is critical for orthoflavivirus infection
Hehner J, Schneider L, Woitalla A, Ott B, Vu KCT, Schöbel A, Hain T, Schwudke D, Herker E
Nat Commun 15(1):8683 2024
doi: 10.1038/s41467-024-52979-y PMID: 39375358 PMCID: PMC11458896

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids
Schöbel A, Pinho Dos Reis V, Burkhard R, Hehner J, Schneider L, Schauflinger M, Vieyres G, Herker E
Commun Biol 7(1):1089 2024
doi: 10.1038/s42003-024-06776-4 PMID: 39237833 PMCID: PMC11377701

Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry
Bley H, Krisp C, Schöbel A, Hehner J, Schneider L, Becker M, Stegmann C, Heidenfels E, Nguyen-Dinh V, Schlüter H, Gerold G, Herker E
J Biol Chem 300(5):107286 2024
doi: 10.1016/j.jbc.2024.107286 PMID: 38636657 PMCID: PMC11101947

Lipid Droplets in Virus Replication
Herker E
FEBS Lett 598(10):1299-1300 2024
doi: 10.1002/1873-3468.14819 PMID: 38348563

Ultrastructural Features of Membranous Replication Organelles Induced by Positive-Stranded RNA Viruses
Nguyen-Dinh V, Herker E
Cells 10(9):2407 2021
doi: 10.3390/cells10092407 PMID: 34572055 PMCID: PMC8464962

Lipid Droplet Contact Sites in Health and Disease
Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M
Trends Cell Biol 31(5):345-358 2021
doi: 10.1016/j.tcb.2021.01.004 PMID: 33546922

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M
Nat Med 16(11):1295-8 2010
doi: 10.1038/nm.2238 PMID: 20935628 PMCID: PMC3431199

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